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Indeed, several recent studies have highlighted the growing concern of weight gain associated with certain ART regimens [2, 5, 29], especially in women [6,7,8] and particularly in women of perimenopausal and menopausal age [9, 11, 30]

IGF-1 exerts protective effects over mitochondria by preserving it from the oxidative damage generated by augmented metabolism, and increasing ATP synthesis and reducing intramitochondrial production of free radicals [105107]

Both are legitimate, mechanistically coherent, and encouraging as far as they go